Mishonga yemishonga yechivanhu yakakosheswa nekufamba kwemakore nekupa ruzivo rwezvirwere zvakawanda.Zvakadaro kupatsanura chaiwo mamorekuru anoshanda kubva kunharaunda yezvakasanganiswa zvinoumba mhando zhinji dzezvirimwa zvinogona kuve basa rakaoma.Iye zvino, vaongorori vepaYunivhesiti yeToyama, Japan vakagadzira nzira yekuzviparadzanisa uye yekuona makomba anoshanda mumishonga yezvirimwa.
Itsva data-yakaburitswa nguva pfupi yadarika muFrontiers in Pharmacology mune chinyorwa chine musoro, "Nzira Yakarongeka Yekutsvaga Mushonga Wekurapa weAlzheimer's Disease uye Yayo Target Molecule.", ratidza kuti nzira nyowani inozivisa akati wandei anoshanda kubva kuDrynaria rhizome, mushonga wechirimwa wechinyakare, unovandudza ndangariro uye kuderedza hunhu hwechirwere mumuenzaniso wembeva yechirwere cheAlzheimer.
Kazhinji, masayendisiti anozogara achiongorora mishonga yemiti isina kuchena mukuyedza kwerabhoritari kuti vaone kana paine makomisheni anoratidza maitiro pamasero anokura mu vitro.Kana komboni ikaratidza kuita kwakanaka mumaseru kana machubhu ekuyedza, inogona kushandiswa semushonga, uye masayendisiti anoenderera mberi nekuiedza mumhuka.Zvakadaro, kuita uku kwakaoma uye hakunei neshanduko dzinogona kuitika kumishonga kana yapinda mumuviri — maenzayimu muropa nechiropa anogona kugadzira mishonga mumhando dzakasiyana-siyana dzinonzi metabolites.Pamusoro pezvo, dzimwe nzvimbo dzemuviri, dzakadai sehuropi, dzinonetsa kuwana mishonga yakawanda, uye mamwe madhiragi chete kana metabolites yavo ndiyo inopinda mumatishu aya.
"Mishonga inocherechedzwa mumishonga yechinyakare yemishonga yechirimwa haisi nguva dzose makemikari anoshanda nekuti mayedzo aya anofuratira biometabolism uye kugoverwa kwetishu," akatsanangura muongorori mukuru Chihiro Tohda, Ph.D., purofesa we neuropharmacology paYunivhesiti yeToyama. ."Saka, isu takavavarira kugadzira nzira dzakasimba dzekuona echokwadi anoshanda makomisheni anotarisisa zvinhu izvi."
Muchidzidzo ichi, timu yeToyama yakashandisa mbeva dzine genetic mutation semuenzaniso wechirwere cheAlzheimer.Kuchinja uku kunopa mbeva humwe hunhu hwechirwere cheAlzheimer, kusanganisira kudzikisira ndangariro uye kuunganidzwa kwemapuroteni chaiwo muuropi, anonzi amyloid uye tau mapuroteni.
"Isu tinoshuma chirongwa chakarongeka chekuongorora avo vanopinda mumishonga yechisikigo inoshandiswa pachirwere cheAlzheimer's (AD)," vanyori vakanyora."Takaona kuti Drynaria rhizome inogona kusimudzira ndangariro uye kunatsiridza AD pathologies mu5XFAD mbeva.Kuongororwa kwebiochemical kwakatungamira mukuzivikanwa kweiyo bioeffective metabolites inotamirwa kuuropi, iyo, naringenin uye yayo glucuronides.Kuti tiongorore magadzirirwo echiito, takabatanidza iyo drug affinity responsive target kugadzikana ne immunoprecipitation-liquid chromatography/mass spectrometry analysis, tichiona collapsin mhinduro murevereri protein 2 (CRMP2) sechinangwa che naringenin. "
Masayendisiti akawana kuti chirimwa chinobvisa chakaderedza kukanganisa kwendangariro uye mazinga eamyloid uye tau mapuroteni muuropi hwegonzo.Uyezve, timu yakazoongorora mbeva yeuropi kwemaawa mashanu mushure mekunge vabata mbeva neinobvisa.Vakaona kuti makemikari matatu emuti wacho akanga apinda muuropi—naringenin uye maviri naringenin metabolites.
Apo vaongorori vakabata mbeva nenaringenin yakachena, vakaona kuvandudzwa kumwechete mukukanganisika kwendangariro uye kudzikiswa kweamyloid uye tau mapuroteni, zvichireva kuti naringenin nemametabolites ayo angangove ndiwo aisanganisa ari mukati mechirimwa.Vakawana puroteni inonzi CRMP2 iyo naringenin inosungira kune neuroni, izvo zvinoita kuti vakure, zvichiratidza kuti iyi inogona kunge iri nzira iyo naringenin inogona kuvandudza zviratidzo zvechirwere cheAlzheimer.
Vanotsvaga vane tarisiro yekuti nzira nyowani inogona kushandiswa kuona mamwe marapirwo."Tiri kushandisa nzira iyi kuti tiwane mishonga mitsva yezvimwe zvirwere zvakadai sekukuvara kwemusana, kuora mwoyo, uye sarcopenia," akadaro Dr. Tohda.
Nguva yekutumira: Mar-23-2022